| High sensitivity of Nrf2 knockout mice to acetoaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzyme and antioxidant genes. | | Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., OﾕConnor, T., Harada, T. and Yamamoto, M. | Toxicol. Sci. 59, 169-177 (2001) | | |
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| Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression. | | Tabata, M., Tarumoto, T., Ohmine, K., Furukawa, Y., Hatake, K., Ozawa, K., Hasegawa, Y., Mukai, H., Yamamoto, M. and Imagawa, S. | J. Cell. Physiol. 186, 260-267 (2001) | | |
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| Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. | | Ramos-Gomez, M., Kwak, M-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P. and Kensler, T. W. | Proc. Natl. Acad. Sci. USA 98, 3410-3415 (2001) | | |
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| Role of Transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemopreventive agent, 3H-1, 2-dithiole-3-thione. | | Kwak, M-K., Itoh, K., Yamamoto, M., Sutter, T. R. and Kensler, T. W. | Mol. Med. 7, 135-145 (2001) | | |
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| Transcription factor BACH1 is recruited to nucleus by its novel alternative spliced isoform expressed in testis. | | Kanezaki, R., Toki, T., Yokoyama, M., Yomogida, K., Sugiyama, K., Yamamoto, M., Igarashi, K. and Ito, E. | J. Biol. Chem. 276, 7278-7284 (2001) | | |
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| Defective development of secretary neurons in the hypothalamus of Arnt2-knockout mice. | | Hosoya, T., Oda, Y., Takahashi, S., Morita, M., Kawauchi, S., Ema, M., Yamamoto, M. and Fujii-Kuriyama, Y. | Genes Cells 6, 361-374 (2001) | | |
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| Function of GATA transcription factors in the induction of endothelial VCAM-1 by TNF-a. | | Umetani, M., Mataki, C., Minegishi, N., Yamamoto, M., Hamakubo, T., and Kodama, T. | Arterioscler. Thromb. Vasc. Biol. 21, 917-922 (2001) | | |
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| Accelerated DNA adducts formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. | | Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K. and Yamamoto, M. | Toxicol. Appl. Pharmacol. 173, 154-160 (2001) | | |
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| Hemin-induced activation of the Thioredoxin gene by Nrf2: a differential regulation of the antioxidant responsive element (ARE) by switch of its binding factors. | | Kim, Y-C., Masutani, H., Yamaguchi, Y., Itoh, K., Yamamoto, M. and Yodoi, J. | J. Biol. Chem. 276, 18399-18406 (2001) | | |
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| Heme mediates de-repression of Maf recognition element through direct binding to transcription factor Bach1. | | Ogawa, K., Sun, J.Y., Taketani, S., Nakajima, O., Nishitani, C., Sassa, S., Hayashi, N., Yamamoto, M., Shibahara, S., Fujita, H. and Igarashi, K. | EMBO J. 20, 2835-2843 (2001) | | |
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| Nrf2 deficient mouse: a novel model for lupus nephritis. | | Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Koyama, A., Yamamoto, M. and Takahashi, S. | Kidney Int. 60, 1343-1353 (2001) | | |
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| Two domains of Nrf2 cooperatively bind CBP (CREB binding protein) and synergistically activate transcription. | | Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A. and Yamamoto, M. | Genes Cells 6, 857-868 (2001) | | |
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| The promoter of mouse transcription repressor bach1 is regulated by Sp1 and transactivated by Bach1. | | Sun, J., Muto, A., Hoshino, H., Kobayashi, A., Nishimura, S., Yamamoto, M., Hayashi, N., Ito, E. and Igarashi, K. | J. Biochem. 130, 385-392 (2001) | | |
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| The Cap' n' Collar basic leucine zipper transcription factor Nrf2 controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. | | McMahon, M., Itoh, K., Yamamoto, M., Chanas, S. A., Henderson, C. J., McLellan, L. I., Wolf, C. R., Cavin, C. and Hayes, J. D. | Cancer Res. 61, 3299-3307 (2001) | | |
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| Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome. | | Imagawa, S., Yamaguchi, Y., Higuchi, M., Neichi, T., Hasegawa, Y., Mukai, H. Y., Suzuki, N., Yamamoto, M. and Nagasawa, T. | Blood 98, 1255-1257 (2001) | | |
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| Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. | | Kwak, M.K., Egner, P.A., Dolan, P.M., Ramos-Gomez, M., Groopman, J.D., Itoh, K., Yamamoto, M. and Kensler, T.W. | Mutat. Res. 480-481, 305-315 (2001) | | |
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| Transgenic overexpression of MafK suppresses T cell proliferation and function in vivo. | | Yoh, K., Sugawara, T., Motohashi, H., Takahama, Y., Koyama, A., Yamamoto, M. and Takahashi, S. | Genes Cells 6, 1055-1066 (2001) | | |
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| Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. | | Kwak, M.K., Itoh, K., Yamamoto, M., Sutter, T.R., Kensler, T.W. | Mol. Med. 7, Mol. Med. 7, 135-145 (2001) | | |
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研究業績 2001 