| The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. | | Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, and Yamamoto M. | Mol Cell Biol 29, 493-502 (2009) | | |
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| Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. | | Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. | Free Radic Biol Med 46, 376-386 (2009) | | |
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| Targeting Nrf2 with the Triterpenoid CDDO-Imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. | | Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S.
| Proc Natl Acad Sci USA 106, 250-255 (2009) | | |
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| Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid treated mice | | Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, and Kensler TW. | Carcinogenesis 30(6), 1024-31 (2009) | | |
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| Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. | | Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, and Yamamoto M. | Clin Cancer Res 15, 3423-3432 (2009) | | |
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| Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. | | Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, and Yamamoto M. | Cancer Prev Res 2, 353-360 (2009) | | |
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| Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of Nrf2 and oxidation of Keap1. | | Takagi T, Naito Y, Okada H, Ishii T, Mizushima K, Akagiri S, Adachi S, Handa O, Kokura S, Ichikawa H, Itoh K, Yamamoto M, Hirofumi M, and Yoshikawa T.
| J Pharmacol Exp Ther 331, 255-264 (2009) | | |
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| The triterpenoid CDDO-Imidazolide confers potent protection against hyperoxic acute lung injury in mice. | | Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, and Reddy SP.
| Am J Respir Crit Care Med 180, 867-874 (2009) | | |
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| Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide. | | Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, and Kensler TW.
| Eur J Pharmacol 620, 138-144 (2009) | | |
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| Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems. | | Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, and Yamamoto M. | Biochem Biophys Res Commun 389, 431-436 (2009) | | |
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| Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-Á production in mice but does not suppress Th2-cytokine production or antibody production. | | Nohara K, Suzuki T, Ao K, Murai H, Miyamoto Y, Inouye K, Pan X, Motohashi H, Fujii-Kuriyama Y, Yamamoto M, and Tohyama C.
| Int Immunol 21, 769-777 (2009) | | |
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| Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse. | | Okano S, Zhou L, Kusaka T, Shibata K, Gao X, Kikuchi Yuko, Togashi Y, Hosoya T, Takahashi S, Nakajima O, and Yamamoto M.
| Genes Cells 15(1), 77-89 (2009) | | |
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Publications 2009 