Publications 2025 
　Original Paper
　
 
Bidirectional regulation of KEAP1 BTB domain-based sensor activity. 
Suzuki T, Takagi K, Iso T, Wen H, Zhang A, Hatakeyama T, Oshima H, Mizushima T, and Yamamoto M.
Redox Biol.    87, 103885.  (2025 Oct 8)
 
G2: an updated version of the Japanese population-specific reference genome. 
Sriwichaiin S, Makino S, Funayama T, Otsuki A, Kawashima J, Okamura Y, Tadaka S, Katsuoka F, Kumada K, Tsutsumi S, Kinoshita K, Yamamoto M, Tamiya G, and Takayama J.
Hum Genome Var   12(1), 21.  (2025 Oct 1)
 
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. 
Takase M, Hirata T, Nakaya N, Kogure M, Hatanaka R, Nakaya K, Chiba I, Tokioka S, Nochioka K, Nakamura T, Tsuchiya N, Metoki H, Satoh M, Narita A, Obara T, Ishikuro M, Ohseto H, Takahashi I, Kobayashi T, Kodama EN, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S, Tamiya G, Hozawa A, Yamamoto M; ToMMo investigators.
Hypertens Res.    48(10), 2606-2617.  (2025 Oct)
 
Cisplatin-induced genetic alterations in KEAP1 promote therapeutic resistance in head and neck squamous cell carcinoma. 
Nakayama Y, Taguchi K, Wakamori S, Uruno A, Otsuki A, Ohkoshi A, Shirota H, Iwasaki T, Katori Y, and Yamamoto M.
Redox Biol.   86, 103819.  (2025 Oc)
 
Elucidation of the structure and molecular mechanisms of the aspartate antiporter.  
Nanatani K, Guan L, Kanno R, Kawabata T, Watanabe S, Katsube S, Hariharan P, Hidaka M, Yamanaka T, Toda K, Fujiki T, Kunii K, Miyamoto A, Chiba F, Ogasawara S, Murata T, Inaba K, Mitsuoka K, Abe K, Yamamoto M, and Koshiba S.
Commun Biol   8(1), 1359.  (2025 Sep 25)
 
Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. 
Takase M, Nakaya N, Kogure M, Hatanaka R, Nakaya K, Chiba I, Tokioka S, Nochioka K, Nakamura T, Tsuchiya N, Hirata T, Kanno I, Narita A, Obara T, Ishikuro M, Ohseto H, Takahashi I, Uruno A, Kobayashi T, Kodama EN, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S, Matsuda K, Izumi Y, Kinoshita K, Tamiya G, Hozawa A, and Yamamoto M.
Clin Kidney J.   18(10), sfaf275.  (2025 Sep 9)
 
NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment. 
Wen H, Suzuki T, Zhang A, Sato M, Matsumoto M, Takahashi Y, Takahashi Y, and Yamamoto M.
iScience.    28(10), 113519.  (2025 Sep 6)
 
Study Profile of the Iwate PGS Assessment and Risk Communication (PARC) Study. 
Yoshida A, Tokutomi T, Suzumori N, Fukushima A, Toya Y, Ohmomo H, Tanno K, Sutoh Y, Kotozaki Y, Hachiya T, Kumada K, Kudo H, Hasegawa A, Sakurai-Yageta M, Narita A, Hamanaka Y, Nagaie S, Ogishima S, Nagami F, Otsuka-Yamasaki Y, Komaki S, Minabe S, Asahi K, Endo R, Ishigaki Y, Yamamoto M, Shimizu A, and Sasaki M.
J Epidemiol.   ,   (2025 Sep 6.)
 
Validity of a self-administered food frequency questionnaire for assessing carotenoid intakes using serum biomarkers in Japan: the Tohoku Medical Megabank Project. 
Murakami K, Yonezawa Y, Obara T, Yamashita T, Suzuki S, Ishihara J, Takachi R, Sugawara S, Aizawa M, Takahashi I, Ishikuro M, Noda A, Kudo H, Kumada K, Yamamoto M, and Kuriyama S.
J Epidemiol.   ,   (2025 Sep 6. )
 
Systemic activation of NRF2 contributes to the therapeutic efficacy of clinically-approved KRAS-G12C anti-cancer drugs. 
Baird L, Zhang L, Hidaka T, Xi L, Wang K, Tateno K, Iso T, Suzuki T, Kumada K, Katsuoka F, Kinoshita K, and Yamamoto M.
Br J Cancer.   ,   (2025 Sep 1.)
 
STAT image reporting in a large-scale cohort: types, frequency, and insights from the Tohoku Medical Megabank Brain MRI Study.  
Mori N, Mugikura S, Abe Y, Hozawa A, Fuse N, and Yamamoto M.
Jpn J Radiol.   43(9), 1413-1416.  (2025 Sep)
 
CD5L is a target of transcription factor Nrf2. 
Dayalan Naidu S, Ang AD, Jia Yee CL, Read OJ, Dixon TS, Knatko EV, Sandilands A, Higgins M, Kisielewski D, Hayes JD, Honda T, Suzuki T, Yamamoto M, and Dinkova-Kostova AT.
Biochem Biophys Res Commun.    776, 152225.  (2025 Aug 30)
 
Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. 
Obara T, Ishikuro M, Noda A, Murakami K, Orui M, Shinoda G, Ueno F, Matsuzaki F, Onuma T, Matsubara H, Metoki H, Kikuya M, Hatanaka R, Chiba I, Nakaya K, Kogure M, Nakaya N, Sugawara J, Kure S, Kobayashi M, Kobayashi T, Suzuki Y, Kawame H, Sakurai-Yageta M, Nagase S, Nakamura N, Nakamura T, Mizuno S, Nagaie S, Ogishima S, Narita A, Tamiya G, Koreeda S, Nagami F, Tamahara T, Goto M, Otsuki A, Taira M, Hidaka T, Kawashima J, Kodama EN, Uruno A, Hamanaka Y, Tomita H, Hashizume H, Noguchi K, Katsuoka F, Koshiba S, Kumada K, Nobukuni T, Ohneda K, Mugikura S, Shimizu R, Kambe M, Saito Y, Kobayashi T, Izumi Y, Kinoshita K, Fuse N, Yaegashi N, Hozawa A, Yamamoto M, and Kuriyama S; Tohoku Medical Megabank Project Study Group.
Int J Epidemiol.   54(5), dyaf148.  (2025 Aug 18)
 
Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. 
Takase M, Nakaya N, Kogure M, Hatanaka R, Nakaya K, Chiba I, Tokioka S, Nochioka K, Nakamura T, Tsuchiya N, Hirata T, Koshiba S, Kumada K, Motoike I, Hishinuma E, Narita A, Obara T, Ishikuro M, Ohseto H, Takahashi I, Kobayashi T, Kodama EN, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S, Matsuda K, Izumi Y, Ohneda K, Kinoshita K, Hozawa A, Yamamoto M; Biobank Japan Project; ToMMo investigators.
Cardiovasc Diabetol.   24(1), 335.  (2025 Aug 14)
 
Nrf2 promotes MWCNT-induced pulmonary inflammation in mice. 
Wu W, Ichihara G, Ikegami A, Suzuki Y, Izuoka K, Ahmed S, Zong C, Itoh K, Yamamoto M, and Ichihara S.
Nanotoxicology.    19(5), 475-488.  (2025 Aug)
 
Development of AI Models for Early Prediction of Preterm Birth. 
Mizuno S, Nagaie S, Tamiya G, Kuriyama S, Obara T, Ishikuro M, Tanaka H, Kinoshita K, Sugawara J, Yamamoto M, Yaegashi N, Saito M, and Ogishima S.
Stud Health Technol Inform.   329, 1932-1933.  (2025 Aug 7)
 
Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study. 
Saito Y, Shimizu M, Sato M, Masuda A, Arisawa K, Taguchi K, Toyama T, Motoike IN, Kinoshita K, Koshiba S, Yamamoto M, and Takamura T.
Sci Rep.   15(1), 25319.  (2025 Jul 13)
 
Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Among Pregnant Women: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 
Murakami K, Nakadate M, Obara T, Aizawa M, Takahashi I, Ishikuro M, Noda A, Ohseto H, Iwama N, Saito M, Takachi R, Sugawara S, Yonezawa Y, Yamashita T, Suzuki S, Ishihara J, Yamamoto M, and Kuriyama S.
J Epidemiol.    35(7), 305-312.  (2025 Jul 5)
 
Efficacy of Nrf2 activation in a proteinuric Alport syndrome mouse model. 
Kaseda S, Horizono J, Sannomiya Y, Kuwazuru J, Suico MA, Sato R, Fukiya H, Sunamoto H, Ogi S, Matsushita T, Koyama Y, Owaki A, Tsuhako H, Shiraga M, Watanabe H, Nakano T, Davenport B, Nozu K, Yamamoto M, Shuto T, Tokunaga Y, Lennon R, Onuma K, and Kai H.
Life Sci Alliance.   8(8), e202503330.  (2025 Jun 17)
 
Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. 
Kobayashi M, Kobayashi T, Obara T, Narita A, Miyake A, Suzuki T, Ishikuro M, Orui M, Kodama EN, Shimizu R, Hamanaka Y, Izumi Y, Hozawa A, Fuse N, Kikuchi A, Tamiya G, Kure S, Kuriyama S, and Yamamoto M.
Tohoku J Exp Med.   ,   (2025 Jun 12.)
 
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies. 
Kodate S, Sato M, Hishinuma E, Kojima K, Motoike IN; ToMMo Study Group; Koshiba S, Yamamoto M, Yamada KD, Kinoshita K.
Sci Rep.   15(1), 17035.  (2025 May 16)
 
Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. 
Fuse N, Anzawa H, Sakurai M, Motoike IN, Nagaie S, Nakamura T, Miyazawa A, Kodama EN, Orui M, Hamanaka Y, Kobayashi T, Uruno A, Taira M, Shimizu R, Nakaya N, Ishikuro M, Obara T, Nagami F, Ogishima S, Katsuoka F, Kumada K, Kuriyama S, Hozawa A, Izumi Y, Kinoshita K, and Yamamoto M.
Ophthalmol Sci.   5(5), 100821.  (2025 May 6)
 
Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases. 
Yamamoto Y, Shirai Y, Sonehara K, Namba S, Ojima T, Yamamoto K, Edahiro R, Suzuki K, Kanai A; BioBank Japan Project; Oda Y, Suzuki Y, Morisaki T, Narita A, Takeda Y, Tamiya G, Yamamoto M, Matsuda K, Kumanogoh A, Yamauchi T, Kadowaki T, and Okada Y.
Nature Commun.    16(1), 3765.  (2025 Apr 28)
 
A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice.  
Scherer T, Metz M, Beghini M, Bilban M, Gensthaler L, Luca AC, Kaplanian M, Abu Eid S, Koldyka O, Hackl MT, Dürr S, Rivelles E, Schönecker SS, Pöltl L, Kaya A, Chami R, Nusko L, Tschare C, Ablaza K, Höbler AL, Klimek P, Leutner M, Yamamoto M, Suzuki N, Stemmer K, Zeyda M, Steinacher D, Nics L, Müller AMS, Helbich TH, Moriggl R, Kautzky-Willer A, Windberger U, Prager G, and Fürnsinn C.
Sci Adv.   11(16), eadt7366.  (2025 Apr 18)
 
Translational genomics of osteoarthritis in 1,962,069 individuals. 
Hatzikotoulas K, … Yamamoto M, …
Nature.     641(8065), 1217-1224.  (2025 May)
 
Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 
Kawaguchi C, Ozawa M, Hidaka T, Murakami K, Ishikuro M, Ueno F, Noda A, Onuma T, Shinoda G, Orui M, Obara T, Ito Y, Kakinuma T, Kudoh K, Ozawa H, Nakagawa S, Mizuashi M, Omori R, Deguchi M, Kanbayashi Y, Asano M, Takahashi T, Tanita M, Hara M, Yamasaki K, Tadaki T, Suzuki H, Kikuchi K, Tsuchiyama K, Ohashi T, Sasai S, Honda M, Fujimura T, Furudate S, Kagimoto Y, Kawamura M, Tabata N, Chikama R, Komatsu H, Sato Y, Tanita K, Kimura Y, Yusa S, Terui H, Tono H, Muto Y, Kuriyama S, Yamamoto M, and Aiba S.
Allergol Int.    74(2), 246-253.  (2025 Apr)
 
The clinical-grade CBP/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs. 
Wang K, Baird L, and Yamamoto M.
Free Radic Biol Med.    233, 102-117.  ( 2025 Jun)
 
Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages. 
Aoyama Y, Yamazaki H, Nishimura K, Nomura M, Shigehiro T, Suzuki T, Zang W, Tatara Y, Ito H, Hayashi Y, Koike Y, Fukumoto M, Tanaka A, Zhang Y, Saika W, Hasegawa C, Kasai S, Kong Y, Minakuchi Y, Itoh K, Yamamoto M, Toyokuni S, Toyoda A, Ikawa T, Takaori-Kondo A, and Inoue D.
Blood    145 (11), 1149-1163.  (2025 Mar 13)
 
Prevalence and Associations of Epiretinal Membrane by OCT in a Japanese Population-Based Cohort: Tohoku Medical Megabank Organization Eye Study. 
Shiraki A, Hirayama A, Fuse N, Kawasaki R, Fujimoto S, Okazaki T, Sakimoto S, Maeno T, Taira M, Saito T, Nakamura T, Ogishima S, Hozawa A, Kinoshita K, Yamamoto M, and Nishida K.
Ophthalmol Sci.   5(4), 100752.  (2025 Feb 26)
 
Validity and Reproducibility of Food Group Intakes in a Self-administered Food Frequency Questionnaire for Genomic and Omics Research: The Tohoku Medical Megabank Project. 
Murakami K, Ishihara J, Takachi R, Sugawara S, Aizawa M, Takahashi I, Obara T, Ishikuro M, Noda A, Ogino M, Hoshina Y, Kito K, Nakadate M, Maruya S, Matsuno T, Yonezawa Y, Yamashita T, Suzuki S, Yamamoto M, and Kuriyama S.
J Epidemiol. 2025 Mar 5; 35 (3): 109-117.   35 (3), 109-117.  (2025 Mar 5)
 
Diverse Cre recombinase expression pattern in Albumin-Cre driver rats.  
Ishida S, Taguchi K, Iida R, Hattori K, Taketsuru H, Yoshimi K, Yamamoto M, and Mashimo T.
Exp Anim.   74(3),  328-334.  ( 2025 Jul 11)
 
Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan.  
Ohneda K, Suzuki Y, Hamanaka Y, Tadaka S, Shimada M, Hasegawa-Minato J, Takahashi M, Fuse N, Nagami F, Kawame H, Kobayashi T, Yamaguchi-Kabata Y, Kinoshita K, Nakamura T, Ogishima S, Kumada K, Kudo H, Kuriyama SI, Izumi Y, Shimizu R, Tochigi M, Motonari T, Tokunaga H, Kikuchi A, Masamune A, Aoki Y, Ishioka C, Ishida T, and Yamamoto M.
J Hum Genet.   70 (3), 147-157.  (2025 Mar)
 
Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project. 
Mori N, Mugikura S, Hozawa A, Taira M, Hashizume H, Sekiguchi A, Abe M, Kasai M, Saito T, Kinoshita K, Fuse N, Kuriyama S, and Yamamoto M.
Tohoku J Exp Med.   267(1), 59-69.  (2025 Sep 20)
 
Anti-Cancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-Activated Esophageal Squamous Cell Carcinoma. 
Oshikiri H, Taguchi K, Hirose W, Taniyama Y, Kamei T, Siegel D, Ross D, Kitson RRA, Baird L, and Yamamoto M.
Mol Cell Biol.    45 (2), 79-97.  (2025)
 
Erythropoietin production in embryonic neural cells is controlled by hypoxia signaling and histone deacetylases with an undifferentiated cellular state. 
Iwamura Y, Nakai T, Kato K, Ishioka H, Yamamoto M, Hirano I, and Suzuki N.
Mol Cell Biol.   45 (1), 32-45  (2025)

　Review
　
 
Health position paper and redox perspectives–Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases. 
Cuadrado A, Cazalla E, Bach A, Bathish B, Dayalan Naidu S, DeNicola GM, Dinkova-Kostova AT, Fernández-Ginés R, Grochot-Przeczek A, Hayes JD, Kensler TW, León R, Liby KT, López MG, Manda G, Kalavathi Shivakumar A, Hakomäki H, Moerland JA, Motohashi H, Rojo AI, Sykiotis GP, Taguchi K, Valverde AM, Yamamoto M, and Levonen A-L.
Redox Biol.   81, 103569  (2025)
 
Role of NRF2 in pathogenesis of Alzheimer’s disease. 
Chu C-T, Uruno A, Katsuoka F, and Yamamoto M.
Antioxidants   13 (12), 1529  (2025)

　日本語著書 (Publications in Japanese)
　

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