研究業績 2004 
　Original Paper
　
 
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). 
Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K. and Yamamoto, M.
Mol. Cell. Biol.   24, 36-45  (2004 )
 
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. 
Kimura-Yoshida C, Kitajima K, Oda-Ishii I, Tian E, Suzuki M, Yamamoto M, Suzuki T, Kobayashi M, Aizawa S, Matsuo I.
Development   131, 57-71  (2004)
 
Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging technique. 
Kyo M, Yamamoto T, Motohashi H, Kamiya T, Kuroita T, Tanaka T, Engel JD, Kawakami B, Yamamoto M.
Genes Cells   9, 153-164  (2004 )
 
Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia. 
Shimizu, R., Ohneda, K., Engel, J.D., Trainor, C.D. and Yamamoto, M.
Blood   103, 2560-2567  (2004)
 
Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages. Activation by Oxidatively Modified LDL and 4-Hydroxynonenal. 
Ishii T, Itoh K, Ruiz E, Leake DS, Unoki H, Yamamoto M, Mann GE.
Circ. Res.   94, 609-616  (2004)
 
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers. 
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang M-I, Kobayashi A, Yamamoto M, Kensler TW, Talalay P
Proc Natl Acad Sci U S A.   101, 2040-2045  (2004)
 
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. 
Kang M-I, Kobayashi A, Wakabayashi N, Kim S-G, Yamamoto M
Proc. Natl. Acad. Sci. U S A.   101, 2046-2051  (2004)
 
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. 
Yoshida S, Takakura A, Ohbo K, Abe K, Wakabayashi J, Yamamoto M, Suda T, Nabeshima Y.
Dev. Biol.   269, 447-458  (2004)
 
Interleukin-6 and tumor necrosis factor-alpha in patients with obstructive sleep apnea-hypopnea syndrome. 
Imagawa S, Yamaguchi Y, Ogawa K, Obara N, Suzuki N, Yamamoto M, Nagasawa T
Respiration   71, 24-29  (2004)
 
Small Maf proteins are obligate transcriptional cofactors for normal keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. 
Motohashi H, Katsuoka F, Engel JD, Yamamoto M
Proc. Natl. Acad. Sci. U S A.   101, 6379-6384  (2004)
 
Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr. 
Morito N, Yoh K, Hirayama A, Itoh K, Nose M, Koyama A, Yamamoto M, Takahashi S.
Kidney Int.   65, 1703-1713  (2004)
 
A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest. 
Ito T, Tsukumo S-i, Suzuki N, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Mimura J, Tien-Min Lin, Richard E.P, Tohyama C, and Nohara K
J. Biol. Chem.   279, 25204-25210  (2004)
 
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. 
Goldring C.E.P., Kitteringham N.R, Elsby R, Randle L.E, Clement Y.N, Williams D.P, McMahon M, Hayes J.D, Itoh K, Yamamoto M, Park B.K.
Hepatology   39, 1267-1276  (2004)
 
In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells. 
Imai T, Kawai Y, Tadokoro Y, Yamamoto M, Nishimune Y, Yomogida K.
Mol. Cell Endocrinol.   214, 107-115  (2004)
 
Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ. 
Yanagawa T, Itoh K, Uwayama J, Shibata Y, Yamaguchi A, Sano T, Ishii T, Yoshida H, Yamamoto M.
Genes Cells.   9, 641-651  (2004)
 
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox sensitive Neh2 degron and the redox-insensitive Neh6 degron. 
McMahon, M., Thomas, N., Itoh, K., Yamamoto, M. and Hayes, J.D.
J. Biol. Chem.   279, 31556-31567  (2004)
 
The transcriptional programme of antibody class switching involves the repressor Bach2. 
Muto A, Tashiro S, Nakajima O, Hoshino H, Takahashi S, Sakoda E, Ikebe D, Yamamoto M, Igarashi K.
Nature   429, 566-571  (2004)
 
The transcription factor Nrf2 protects against pulmonary fibrosis. 
Cho HY, Reddy SP, Yamamoto M, Kleeberger SR.
FASEB J.   18, 1258-1260  (2004)
 
MafT, a new member of the small Maf protein family in zebrafish. 
Takagi Y, Kobayashi M, Li L, Suzuki T, Nishikawa K, Yamamoto M.
Biochem. Biophys. Res. Commun.   320, 62-69  (2004)
 
Oxidative stress sensor keap1 functions as an adaptor for cul3-based e3 ligase to regulate proteasomal degradation of nrf2. 
Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.
Mol. Cell. Biol.   24, 7130-7139  (2004)
 
Identification of polymorphisms in the promoter region of the human NRF2 gene. 
Yamamoto T, Yoh K, Kobayashi A, Ishii Y, Kure S, Koyama A, Sakamoto T, Sekizawa K, Motohashi H, Yamamoto M.
Biochem. Biophys. Res. Commun.   321, 72-79  (2004)
 
Do beta-globin, GATA-1,or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice? 
Suzuki N, Imagawa S, Noguchi CT, Yamamoto M.
Blood   104, 2988  (2004)
 
Multiple, Distant Gata2 Enhancers Specify Temporally and Tissue-Specific Patterning in the Developing Urogenital System. 
Khandekar, M., Suzuki, N., Lewton, J., Yamamoto M, and Engel, J.D.
Mol. Cell. Biol.   24, 10263-10276  (2004)
 
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. 
Iida K, Itoh K, Kumagai Y, Oyasu R, Hattori K, Kawai K, Shimazui T, Akaza H, Yamamoto M.
Cancer Res.   64, 6424-6431  (2004)
 
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. 
Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S.
J. Clin. Invest.   114, 1248-1259  (2004)
 
Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. 
Nakano Y, Imagawa S, Matsumoto K, Stockmann C, Obara N, Suzuki N, Doi T, Kodama T, Takahashi S, Nagasawa T, Yamamoto M.
Blood   104, 4300-4307  (2004)
 
Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. 
McWalter GK, Higgins LG, McLellan LI, Henderson CJ, Song L, Thornalley PJ, Itoh K, Yamamoto M, Hayes JD.
J. Nutr.   134, 3499S-3506S  (2004)
(Suppl)
 
Leukemogenesis caused by incapacitated GATA-1 function. 
Shimizu, R., Kuroha, T., Ohneda, O., Pan, X., Ohneda, K., Takahahshi, S., Philipsen, S., Yamamoto, M.
Mol. Cell. Biol.   24, 10814-10825  (2004)
 
Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. 
Kobayashi, A., Ohta, T. and Yamamoto, M.
Methods Enzymol.   378, 273-286  (2004)
(invited review)
 
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. 
Itoh, K., Tong, K.I. and Yamamoto, M.
Free Radical Biol. Med.   36, 1208-1213  (2004)
(nvited review)
 
Nrf2-Keap1 defines a physiologically important stress response mechanism. 
Motohashi, H. and Yamamoto, M.
Trends Mol. Med.   10, 549-557  (2004)
(invited review)

　日本語著書 (Publications in Japanese)
　
 
酸化ストレス応答/ 転写制御 
山本多恵・山本雅之
酸化ストレスマーカー   （二木鋭雄，野口範子，内田浩二編；学会出版センター）, 153-158  (2004)
 
組織特異的遺伝子発現 
小原 直・鈴木教郎・山本雅之
キーワードで理解する転写イラストマップ   （田村隆明編）, 139-149  (2004)
 
遺伝子発現とクロマチン 
西川恵三・山本雅之
Molecular Medicine   41 増刊号 ヒトゲノムー生命システムの理解と医学への展開, 110-117  (2004)
 
GATA転写因子からみる赤血球の発生・分化 
長野真澄，山本雅之
実験医学   22, 361-366  (2004)
 
親電子性物質応答の分子機構 
伊東 健，山本雅之
生化学   76, 339-348  (2004)
 
Keap1-Nrf2システムによる抗酸化酵素群の統一的発現制御機構 
細谷朋方，山本雅之
分子呼吸器病   8, 147-150  (2004)
 
血色素の分子進化 
鈴木教郎，山本雅之
日本医事新報   4177, 99-100  (2004)
 
転写因子と血液疾患 
峯岸直子，山本雅之
臨床検査   48, 473-481  (2004)
 
GATA-1ノックダウンマウス 
清水律子，山本雅之
Mebio   21, 58-62  (2004)
 
GATA-1変異と白血病-転写因子の質的異常と量的異常 
長野真澄，清水律子，山本雅之
医学の歩み   211, 159-162  (2004)

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