研究業績 2005 
 Original Paper
 
 
Gene expression profiling of NRF2-mediated protection against oxidative injury.  
Cho, H-Y., Reddy, S.P., DeBiase, A., Yamamoto, M. and Kleeberger, S.R.
Free Rad. Biol. Med.   38, 325– 343  (2005)
 
An activator protein-1-Notch-4 angiogenic vascular remodeling pathway. 
Wu, J., Iwata, F., Grass, J.A., Elnitski, L., Ohneda, O., Yamamoto, M., and Bresnick, E.H.
Mol. Cell. Biol.   25, 1458-1474  (2005)
 
Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells. 
Nakano M, Ohneda K, Yamamoto-Mukai H, Shimizu R, Ohneda O, Ohmura S, Suzuki M, Tsukamoto S, Yanagawa T, Yoshida H, Takakuwa Y, Yamamoto M.
Genes Cells   10, 47-62  (2005)
 
Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment. 
Toki, T., Katsuoka, F., Kanezaki, R., Xu, G., Kurotaki, H., Sun, J., Kamio, T., Watanabe, S., Tandai, S., Terui, K., Yagihashi, S., Komatsu, N., Igarashi, K., Yamamoto, M. and Ito, E.
Blood   105, 3100-3108  (2005)
 
Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. 
Katsuoka F, Motohashi H, Engel JD, Yamamoto M.
J. Biol. Chem.   280, 4483-4490  (2005)
 
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. 
Katoh, Y., Iida, K., Kang, M-I., Kobayashi, A., Mizukami, M., Tong, K.I., McMahon, M., Hayes, J.D., Itoh, K. and Yamamoto, M.
Arch. Biochem. Biophys.   433, 342-350  (2005)
 
Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1. 
Padmanabhan, B., Scharlock, M., Tong, K.I., Nakamura, Y., Kang, M-I., Kobayashi, A., Matsumoto, T., Tanaka, A., Yamamoto, M. and Yokoyama, S
Acta Crystallographica   61, 153-155  (2005)
 
Essential role of synoviolin in embryogenesis. 
Yagishita, N., Ohneda, K., Amano, T., Yamasaki, S., Sugiura, A., Tsuchimochi, K., Shin, H., Kawahara, K., Ohneda, O., Ohta, T., Tanaka, S., Yamamoto, M., Maruyama, I., Nishioka, K., Fukamizu, A. and Nakajima, T.
J. Biol. Chem.   280, 7909-7916  (2005)
 
Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes. 
Nohara, K., Pan, X., Tsukumo, S., Hida, A., Ito, T., Nagai, H., Inouye, K., Motohashi, H., Yamamoto, M., Fujii-Kuriyama, Y. and Tohyama, C.
J. Immunol.   174, 2770-2777  (2005)
 
Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish. 
Suzuki, T., Takagi, Y., Osanai, H., Li, L., Takeuchi, M., Katoh, Y., Kobayashi, M. and Yamamoto, M.
Biochem. J.   388, 65-73  (2005)
 
UVA irradiation induces Nrf2 activation in dermal fibroblasts: Protective role in UVA-induced apoptosis. 
Hirota, A., Kawachi, Y., Itoh, K., Nakamura, Y., Xu, X., Banno, T., Takahashi, T., Yamamoto, M. and Ohtsuka, F.
J. Invest. Dermatol.   124, 825-832  (2005)
 
The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis. 
Kelly, V.P., Suzuki, T., Nakajima, O., Arai, T., Tamai, Y., Takahashi, S., Nishimura, S. and Yamamoto, M.
Mol. Cell. Biol.   25, 3658-3669  (2005)
 
GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity. 
Ezoe, S., Matsumura, I., Gale, K., Satoh, Y., Ishikawa, J., Mizuki, M., Takahashi, S., Minegishi, N., Nakajima, K., Yamamoto, M., Enver, T. and Kanakura, Y.
J Biol Chem.   280, 13163-13170  (2005)
 
Role of 15-deoxyD12-14 prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. 
Mochizuki, M., Ishii, Y., Itoh, K., Iizuka, T., Morishima, Y., Kimura, T., Kiwamoto, T., Matsuno, Y., Hegab, A. E., Nomura, A., Sakamoto, T., Uchida, K., Yamamoto, M. and Sekizawa, K.
Am. J. Respir. Crit. Care. Med.   171, 1260-1266  (2005)
 
Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. 
Yanagida, M., Osato, M., Yamashita, N., Liqun, H., Jacob, B., Wu, F., Cao, X., Nakamura, T., Yokomizo, T., Takahashi, S., Yamamoto, M., Shigesada, K. and Ito, Y.
Oncogene.    24, 4477-4485  (2005)
 
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway. 
Minegishi, N., Suzuki, N., Kawatani, Y., Shimizu, R. and Yamamoto, M.
Genes Cells   10, 693-704  ( 2005)
 
MafA is a key regulator of glucose-stimulated insulin secretion. 
Zhang, C., Moriguchi, T., Kajihara, M., Esaki, R., Harada, A., Shimohata, H., Oishi, H., Hamada, M., Morito, N., Hasegawa, K., Kudo, T., Engel, J.D., Yamamoto, M. and Takahashi, S.
Mol. Cell. Biol.    25, 4969-4976  (2005)
 
Graded levels of GATA-1 expression modulate survival proliferation and differentiation of erythroid progenitors. 
Pan, X., Ohneda, O., Ohneda, K., Lindeboom, F., Iwata, F., Shimizu, R., Nagano, M., Suwabe, N., Philipsen, S., Lim, K-C., Engel, J.D. and Yamamoto, M.
J. Biol. Chem.   280, 22385-22394  (2005)
 
Novel serpinopathy in rat kidney and pancreas induced by overexpression of Megsin. 
Inagi, R., Nangaku, M., Usuda, N., Shimizu, A., Onogi, H., Izuhara, Y., Nakazato, K., Ueda, Y., Oishi, H., Takahashi, S., Yamamoto, M., Suzuki, D., Kurokawa, K., van Ypersele de Strihou, C. and Miyata, T.
J. Am. Soc. Nephrol.   16, 1339-1349  (2005)
 
Selective induction of a tumor marker glutathione S-transferase P1 by proteasome inhibitors. 
Usami, H., Kusano, Y., Kumagai, T., Osada, S., Itoh, K., Kobayashi, A., Yamamoto, M. and Uchida, K.
J. Biol. Chem.   280, 25267-25276  (2005)
 
GATA motifs regulate early hematopoietic lineage-specific expression of Gata2 gene. 
Kobayashi-Osaki, M., Ohneda, O., Suzuki, N., Minegishi, N., Yokomizo, T., Takahashi, S., Lim, K-C., Engel, J.D. and Yamamoto, M.
Mol. Cell. Biol.    25, 7005-7020  (2005)
 
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. 
Zhu H, Itoh K, Yamamoto M, Zweier JL, Li Y.
FEBS Lett.   579, 3029-3036  (2005)
 
Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. 
Hosoya, T., Maruyama, A., Kang, M-I., Kawatani, Y., Shibata, T., Uchida, K., Itoh, K. and Yamamoto, M.
J. Biol. Chem.    280, 27244-27250  (2005)
 
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. 
Rangasamy, T., Guo, J., Mitzner, W.A., Roman, J., Singh, A., Fryer, A.D., Yamamoto, M., Kensler, T.W., Tuder, R.M., Georas, S.N. and Biswal, S.
J. Exp. Med.   202, 47-59  (2005)
 
GATA-1 is required for expression of Fc{epsilon}RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. 
Nishiyama, C., Ito, T., Nishiyama, M., Masaki, S., Maeda, K., Nakano, N., Ng, W., Fukuyama, K., Yamamoto, M., Okumura, K., Ogawa, H.
Int. Immunol.   17, 847-856  (2005)
 
Genetic evidence that small Maf proteins are essential for the activation of antioxidant response element-dependent genes. 
Katsuoka, F., Motohashi, H., Ishii, T., Aburatani, H., Engel, J. D. and Yamamoto, M.
Mol. Cell. Biol.   25, 8044-8051  (2005)
 
Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. 
Tauchi, M., Hida, A., Negishi, T., Katsuoka, F., Noda, S., Mimura, J., Hosoya, H., Yanaka, A., Aburatani, H., Fujii-Kuriyama, Y., Motohashi, M. and Yamamoto, M.
Mol. Cell. Biol.    25, 9360-9368  (2005)
ダイオキシン受容体の過剰発現マウスはアトピー性皮膚炎様の症状を示す
 
Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor. 
Kato, H., Ishida, J, Imagawa, S., Saito, T., Suzuki, N., Matsuoka, T., Sugaya, T., Tanimoto, K., Yokoo, T., Ohneda, O., Sugiyama, F., Yagami, K. I., Fujita, T., Yamamoto, M., Nangaku, M., an Fukamizu, A.
FASEB J.   19, 2023-2025  (2005)
 
Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. 
Baba, T., Mimura, J., Nakamura, N., Harada, N., Yamamoto, M., Morohashi, K. and Fujii-Kuriyama, Y.
Mol. Cell. Biol.   25, 10040-10051  (2005)
 
Gene expression profiling of NRF2-mediated protection against oxidative injury.  
Cho, H-Y., Reddy, S.P., DeBiase, A., Yamamoto, M. and Kleeberger, S.R.
Free Rad. Biol. Med.   38, 325– 343  (2005)
 
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. 
Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K.
Genes Cells   10, 1113-1125  (2005)
 
Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress. 
Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka N, Yamamoto M.
Inflammopharmacology.   13, 83-90  (2005)
 
Role of 15-deoxyD12-14 prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. 
Mochizuki, M., Ishii, Y., Itoh, K., Iizuka, T., Morishima, Y., Kimura, T., Kiwamoto, T., Matsuno, Y., Hegab, A. E., Nomura, A., Sakamoto, T., Uchida, K., Yamamoto, M. and Sekizawa, K.
Am. J. Respir. Crit. Care. Med.   171, 1260-1266  (2005)
 
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. 
Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K.
Genes Cells   10, 1113-1125  (2005)
 
Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress. 
Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka N, Yamamoto M.
Inflammopharmacology.   13, 83-90  (2005)
 
Regulatory role of the COX-2 pathway in the Nrf2-mediated anti-inflammatory response.  
Itoh, K. and Yamamoto, M.
J. Clin. Biochem. Nutri.   37, 9-18  (2005)

 日本語著書 (Publications in Japanese)
 
 
Nrf2による酸化ストレス応答 
丸山敦史,伊東健
医学のあゆみ   別冊 レドックス―ストレス防御の医学, 147-150  (2005)
 
血液疾患に対する発生工学的アプローチー転写因子GATA-1の機能破綻と血液疾患 
清水律子,山本雅之
別冊・医学の歩み 血液疾患   Ver. 3, 187-190  (2005)
 
2-oxoglutarateによる血管形成抑制 
松本 健, 今川重彦, 小原 直, 鈴木教郎, 長澤俊郎, 山本雅之
医学のあゆみ   215, 158-159  (2005)
 
モデル生物が切り開く造血発生研究の新展開 
大根田絹子, 山本雅之
蛋白質核酸酵素   50 増刊号「発生システムのダイナミクス」, 633-637  (2005)

[編集]
CGI-design