Publications 2011 
　Original Paper
　
 
Molecular determinants for small Maf protein control of platelet production. 
Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M.
Mol Cell Biol.   31, 151-62  (2011)
 
Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia. 
Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M.
Blood.   117, 986-96  (2011)
技術員の川谷さんの論文です
 
Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. 
Tsujita T, Li L, Nakajima H, Iwamoto N, Nakajima-Takagi Y, Ohashi K, Kawakami K, Kumagai Y, Freeman BA, Yamamoto M, Kobayashi M.
Genes Cells.   16, 46-57  (2011)
 
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. 
Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou YS, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M.
Nat Commun.   2, 181  (2011)
 
Inducible disruption of autophagy in the lung causes airway hyper-responsiveness. 
Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M.
Biochem Biophys Res Commun.   405, 13-18  (2011)
 
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages. 
Harada N, Kanayama M, Maruyama A, Yoshida A, Tazumi K, Hosoya T, Mimura J, Toki T, Maher JM, Yamamoto M, Itoh K.
Arch Biochem Biophys.   508, 101-109  (2011)
 
Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers. 
Hirotsu Y, Katsuoka F, Itoh K, Yamamoto M
Genes Cells   16 , 406-415  (2011)
大学院生の弘津さんの論文です
 
Acute erythropoietin cardioprotection is mediated by endothelial response. 
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT.
Basic Res Cardiol.   106, 343-354  (2011)
 
Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. 
Souma T, Abe M, Moriguchi T, Takai J, Yanagisawa-Miyazawa N, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S.
J Am Soc Nephrol.   22, 635-648  (2011)
大学院生の相馬さんの論文です
 
Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. 
You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK.
Arch Biochem Biophys.   507, 356-364  (2011)
 
Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo. 
Suzuki T, Maher J, Yamamoto M.
Cancer Res.   71, 1700-1709  (2011)
鈴木隆史助教の論文です
 
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism. 
Kansanen E, Bonacci G, Schopfer FJ, Kuosmanen SM, Tong KI, Leinonen H, Woodcock SR, Yamamoto M, Carlberg C, Ylä-Herttuala S, Freeman BA, Levonen AL.
J Biol Chem.   286, 14019-14027  (2011)
 
Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2. 
Watanabe-Matsui M, Muto A, Matsui T, Itoh-Nakadai A, Nakajima O, Murayama K, Yamamoto M, Ikeda-Saito M, Igarashi K.
Blood   117, 5438-5448  (2011)
 
Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy. 
Li J, Zhang C, Xing Y, Janicki JS, Yamamoto M, Wang XL, Tang DQ, Cui T.
Cardiovasc Res.   90, 315-324  (2011)
 
Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice. 
Yageta Y, Ishii Y, Morishima Y, Masuko H, Ano S, Yamadori T, Itoh K, Takeuchi K, Yamamoto M, Hizawa N.
J Virol.   85, 4679-4690  (2011)
 
Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages. 
Kuhn AM, Tzieply N, Schmidt MV, von Knethen A, Namgaladze D, Yamamoto M, Brüne B.
Free Radic Biol Med.   50, 1382-1391  (2011)
 
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. 
Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, Yamamoto M.
Genes Cells   16, 692-703  (2011)
 
Initial Response and Cellular Protection through the Keap1/Nrf2 System during the Exposure of Primary Mouse Hepatocytes to 1,2-Naphthoquinone. 
Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y.
Chem Res Toxicol.   24, 559-567  (2011)
 
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. 
Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M.
J Cell Biol.   193, 275-284  (2011)
 
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. 
Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev AT, Kisielow J, Hersberger M, Yamamoto M, Bachmann MF, Kopf M.
Eur J Immunol.   41, 2040-2051  (2011)
 
Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury. 
Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y.
Environ Health Perspect.   119, 1117-1122  (2011)
 
Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes. 
Mimura J, Kosaka K, Maruyama A, Satoh T, Harada N, Yoshida H, Satoh K, Yamamoto M, Itoh K.
J Biochem.   150, 209-217  (2011)
 
Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice. 
Hirota A, Kawachi Y, Yamamoto M, Koga T, Hamada K, Otsuka F.
Exp Dermatol.   20, 664-668  (2011)
 
NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer. 
Shibata T, Kokubu A, Saito S, Narisawa-Saito M, Sasaki H, Aoyagi K, Yoshimatsu Y, Tachimori Y, Kushima R, Kiyono T, Yamamoto M.
Neoplasia   13, 864-873  (2011)
 
Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages. 
Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, Yamamoto M.
Mol Cell Biol   31, 3896-3905  (2011)
 
Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1. 
Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL.

J Biochem Mol Toxicol   25, 320-329  (2011)
 
Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway. 
Kalra S, Zhang Y, Knatko EV, Finlayson S, Yamamoto M, Dinkova-Kostova AT.
Cancer Prev Res (Phila)   4, 1665-1674  (2011)
 
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. 
Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M.

J Clin Invest   121, 3981-3990  (2011)
 
Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice. 
Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, Yamamoto M.

PLoS One   6, e25839  (2011)
 
Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival. 
Wong TF, Yoshinaga K, Monma Y, Ito K, Niikura H, Nagase S, Yamamoto M, Yaegashi N.

Int J Gynecol Cancer   21, 1428-1435  (2011)
 
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. 
Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, Ho E.
Pharm Res   28, 3171-3179  (2011)
 
Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. 
Nakajima H, Nakajima-Takagi Y, Tsujita T, Akiyama S, Wakasa T, Mukaigasa K, Kaneko H, Tamaru Y, Yamamoto M, Kobayashi M.
PLoS One   6, e26884  (2011)
 
Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice. 
Bauer AK, Cho HY, Miller-Degraff L, Walker C, Helms K, Fostel J, Yamamoto M, Kleeberger SR.
PLoS One   6, e26590  (2011)
 
Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. 
Hoshino T, Tabuchi K, Nishimura B, Tanaka S, Nakayama M, Ishii T, Warabi E, Yanagawa T, Shimizu R, Yamamoto M, Hara A.
Biochem Biophys Res Commun   415, 94-98  (2011)
 
Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production. 
Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT.
Nat Commun   2, 520  (2011)

　日本語著書 (Publications in Japanese)
　
 
EPO遺伝子の発現制御と産生細胞の同定 
鈴木教郎, 山本雅之
腎と透析   71, 183–192  (2011)

　Review
　
 
Transcriptional regulation by GATA1 and GATA2 during erythropoiesis. 
Suzuki M, Shimizu R, Yamamoto M.
Int J Hematol.   93, 150-155  (2011)
 
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. 
Taguchi K, Motohashi H, Yamamoto M.
Genes Cells.   16, 123-140  (2011)
田口恵子助教の総説です
 
The Keap1-Nrf2 system as an in vivo sensor for electrophiles. 
Uruno A, Motohashi H.
Nitric Oxide   25, 153-160  (2011)
宇留野助教による総説です

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