Publications 2012 
　Original Paper
　
 
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.  
Yamazaki H, Katsuoka F, Motohashi H, Engel JD, Yamamoto M.
Mol Cell Biol   32, 808-816  (2012)
大学院生の山㟢（中山）博未さんの論文です。
 
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J.
Free Radic Biol Med   52, 462-472  (2012)
 
Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction. 
Hancock R, Bertrand HC, Tsujita T, Naz S, El-Bakry A, Laoruchupong J, Hayes JD, Wells G.
Free Radic Biol Med.   52, 444-451  (2012)
 
Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. 
Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N.
Free Radic Biol Med   52, 1708-1715  (2012)
 
Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. 
Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M.
Cancer Sci.   103, 760-766  (2012)
 
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. 
Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ.
J Pharmacol Exp Ther.   341, 274-284  (2012)
 
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. 
Xue M, Rabbani N, Momiji H, Imbasi P, Anwar MM, Kitteringham N, Park BK, Souma T, Moriguchi T, Yamamoto M, Thornalley PJ
Biochem J.   443, 213-222  (2012)
 
UG4 enhancer-driven GATA-2 and BMP4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice. 
Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M.
Mol Cell Biol.   32(12), 2312-2322  (2012)
大学院生相野谷慶子さんの論文です
 
Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage. 
Jia Y, Suzuki N, Yamamoto M, Gassmann M, Noguchi CT.
FASEB    26(7), 2847-2858  (2012)
 
Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy. 
Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT.
Cancer Prev Res (Phila).   5(7), 973-981  (2012)
 
Targeted Deletion of Nrf2 Impairs Lung Development and Oxidant Injury in Neonatal Mice. 
Cho HY, van Houten B, Wang X, Miller-Degraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, Kleeberger SR.
Antioxid Redox Signal.   17(8), 1066-82  (2012)
 
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. 
Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M.
Free Radic Biol Med.    53（4）, 817-27  (2012)
大学院生高屋快さんの論文です。
 
Keap1 degradation by autophagy for the maintenance of redox homeostasis. 
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
Proc Natl Acad Sci U S A.    109(34), 13561-6.  (2012)
田口恵子助教と大学院生藤川奈々子さんの論文です
 
Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. 
Abdullah A, Kitteringham NR, Jenkins RE, Goldring C, Higgins L, Yamamoto M, Hayes J, Park BK.
Pharmacol Rep.   64（3）, 680-97  (2012)
 
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. 
Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H.
Cancer Cell.   22（1）, 66-79  (2012)
大学院生光石陽一郎さんの論文です
 
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis 
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J.
J Gastroenterol.   47（8）, 924-35  (2012)
 
Heme and heme biosynthesis intermediates induce Heme oxygenase-1 and Cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: Different requirement for transcription factor Nuclear factor erythroid-derived 2-like 2. 
Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J.
Toxicol Sci.   Nov;130(1), 132-144  (2012)
 
Correction: Tissue-Restricted Expression of Nrf2 and Its Target Genes in Zebrafish with Gene-Specific Variations in the Induction Profiles. 
Nakajima H, Nakajima-Takagi Y, Tsujita T, Akiyama SI, Wakasa T, Mukaigasa K, Kaneko H, Tamaru Y, Yamamoto M, Kobayashi M.
PLoS One   7(9),   (2012)
 
Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor. 
Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Saido T, Minegishi N, Miyata T, Abe T, Yamamoto M.
Neurobiol Dis.   Dec;48(3), 556-567  (2012)
 
Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks. 
Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Douglas Engel J, Yamamoto M.
Nucleic Acids Res.   Nov 1;40(20), 10228-39  (2012)
大学院生弘津陽介さんの論文です
 
Genetic Evidence of an Evolutionarily Conserved Role for Nrf2 in the Protection against Oxidative Stress. 
Mukaigasa K, Nguyen LT, Li L, Nakajima H, Yamamoto M, Kobayashi M.
Mol Cell Biol    Nov;32(21), 4455-61  (2012)
 
Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. 
Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, Camper SA, Yamamoto M, Engel JD.
J Clin Invest.   Oct 1;122(10), 3705-17  (2012)
 
Regulation of GATA Factor Expression Is Distinct between Erythroid and Mast Cell Lineages. 
Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, Yamamoto M, Ohneda K.
Mol Cell Biol.   Dec;32(23), 4742-55.  (2012)
 
Mitochondrial SKN-1/Nrf mediates a conserved starvation response. 
Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP.
Cell Metab.   16(4), 526-37  (2012)
 
Selective isotope labeling of recombinant proteins in Escherichia coli. 
Tong KI, Yamamoto M, Tanaka T.
Methods Mol Biol   896, 439-448  (2012)
 
Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction. 
Hasegawa A, Shimizu R, Mohandas N, Yamamoto M.
Blood   119(11), 2615-23  (2012)
大学院生　長谷川敦史さんの論文です
 
N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program. 
Kaneko H, Kobayashi E, Yamamoto M, Shimizu R.
J Biol Chem   287(25), 21439-49  (2012)
金子寛助教の論文です
 
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes. 
Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
Mol Cell Biol.   32(14), 2760-70  (2012)
大学院生弘津陽介さんと旗谷奈未さんの論文です
 
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. 
Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.
Nat Chem Biol.   8(8), 714-24  (2012)
 
Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation. 
Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami K, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K.
Free Radic Biol Med.   53, 2256-2262  (2012)
 
Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease. 
Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B.
Antioxid Redox Signal.   18, 139-157  (2012)

　日本語著書 (Publications in Japanese)
　
 
Keap1-Nrf2ストレス応答系による病態制御 
山本 雅之
臨床神経学   52, 861  (2012)
 
活性酸素種や親電子性物質におるシグナル伝達 
田口恵子、山本雅之
実験医学   30（５）, 759-765  (2012)
 
ユビキチンープロテアソーム系によるKeap1-Nrf2経路の制御機構 
鈴木隆史、山本雅之
医学のあゆみ   234, 525-529  (2012)
 
活性酸素・ガス状分子による恒常性制御と疾患〜酸化ストレス応答と低酸素センシングの最新知見からがん,免疫,代謝・呼吸・循環異常,神経変性との関わりまで 
山本雅之
実験医学   10月増刊号,   (2012)
 
代謝リプログラミングにおける酸化ストレス応答機構の役割 
田口恵子、本橋ほづみ
実験医学　2012増刊号   30（17）, 2814-2521  (2012)
 
腎性貧血とエリスロポエチン 
鈴木教郎
透析療法ネクスト   XIV, 15-25  (2012)
 
エリスロポエチン遺伝子の発現制御機構 
鈴木教郎
第２０回腎とエリスロポエチン研究会   , 113-118  (2012)
 
低酸素応答の臓器特異的制御ー低酸素誘導的・組織特異的エリスロポエチン遺伝子の発現制御機構 
鈴木教郎
血管医学   13, 333-339  (2012)
 
セクレチン 
西島維知子
Clinical Neuroscience（臨床神経科学）   30, 216-217  (2012)
 
酸化ストレスシグナルとKeap1-Nrf2システムの役割 
村上昌平、本橋ほづみ
細胞工学   31, 144-149  (2012)

　Review
　
 
Contribution of GATA1 dysfunction to multi-step leukemogenesis. 
Shimizu R, Yamamoto M.
Cancer Sci.   103(12), 2039-44  (2012)
 
The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. 
Mitsuishi Y, Motohashi H, and Yamamoto M
Front Oncol    2, 200  (2012)

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