研究業績 2006 
　Original Paper
　
 
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. 
Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M.
Biochem. Biophys. Res. Commun.   339, 79-88  (2006)
 
A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol. 
Umemura T, Kuroiwa Y, Kitamura Y, Ishii Y, Kanki K, Kodama Y, Itoh K, Yamamoto M, Nishikawa A, Hirose M.
Toxicol. Sci.   90, 111-119  (2006)
 
Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway. 
Nagai H, Kubo M, Abe R, Yamamoto M, Nohara K.
Int. Immunopharmacol.   6, 279-286  (2006)
 
Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. 
Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, Yamada A, Maeda A, Matsuno F, Hata H, Suzuki A, Imagawa S, Mitsuya H, Esumi H, Koyama A, Yamamoto M, Mori N, Takahashi S.
Cancer Res.   66, 812-819  (2006)
 
Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes. 
Fujiwara T, Harigae H, Takahashi S, Furuyama K, Nakajima O, Sun J, Igarashi K, Yamamoto M, Sassa S, Kaku M, Sasaki T.
Biochem. Biophys. Res. Commun.   340, 105-110  (2006)
 
Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche. 
Suzuki N, Ohneda O, Minegishi N, Nishikawa M, Ohta T, Takahashi S, Engel JD, Yamamoto M.
Proc. Natl. Acad. Sci. USA   103, 2202-2207  (2006)
 
Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. 
Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H, Karibe A, Minegishi N, Suzuki N, Yamamoto M, Ono M, Watanabe J, Shirato K, Ishii N, Sugamura K, Shimokawa H.
Circulation   113, 1442-1450  (2006)
 
Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer. 
Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M.
Mol. Cell   21, 689-700  (2006)
 
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. 
Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M.
Mol. Cell. Biol.   26, 2887-2900  (2006)
 
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. 
Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S.
J. Clin. Invest.   116, 984-995  (2006)
 
Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements. 
Yamamoto, T., Kyo, M., Kamiya, T., Tanaka, T., Engel, J.D., Motohashi, M. and Yamamoto, M.
Genes Cells   11, 575-591  (2006)
 
Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes. 
Nakajima O, Okano S, Harada H, Kusaka T, Gao X, Hosoya H, Suzuki N, Takahashi S, Yamamoto M.
Genes Cells   11, 685-700  (2006)
 
MafG sumoylation is required for active transcriptional repression. 
Motohashi H, Katsuoka F, Miyoshi C, Uchimura Y, Saitoh H, Francastel C, Engel JD, Yamamoto M.
Mol. Cell. Biol.   26, 4652-4663  (2006)
 
MafB is essential for renal development and F4/80 expression in macrophage. 
Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Engel JD, Yamamoto M, Takahashi S.
Mol. Cell. Biol.   26, 5715-5727  (2006)
 
Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress. 
Zhu H, Zhang L, Itoh K, Yamamoto M, Ross D, Trush MA, Zweier JL, Li, Y
Free Radic. Biol. Med.   41, 132-143  (2006)
 
In vitro differentiation of mouse ES cells into haematopoietic cells.  
Ohneda, O. and Yamamoto, M.
OUP Practical Approach on Embryonic Stem Cells    (Notarianni, E. and Evans, M.J, eds.), 169-188  (2006)
 
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. 
Tong KI, Kobayashi A, Katsuoka F, Yamamoto M.
Biol Chem.    387, 1311-1320  (2006)
本号の表紙に選ばれました。
 
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs is regulated by Nrf2.  
Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohe R, Kensler TW, Yamamoto M, Biswal S.
Am. J. Respir. Cell. Mol. Biol   35, 639−650  (2006)
 
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a 'tethering' mechanism: A two-site interaction model for the Nrf2-Keap1 complex.  
McMahon MJ, Thomas N, Itoh K, Yamamoto M, Hayes JD
J. Biol. Chem.    281, 24756-24768  (2006)
 
Ebselen, a seleno-organic antioxidant, as an electrophile.  
Sakurai T, Kanayama M, Shibata T, Itoh K, Kobayashi A, Yamamoto M, Uchida K.
Chem. Res. Toxicol.   19, 1196-1204  (2006)
 
GATA-3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation.  
Moriguchi, T., Nakano, T., Hamada, M., Maeda, A., Fujioka, Y., Kuroha, T., Huber, R., Hasegawa, S., Rao, A., Yamamoto, M., Takahashi, S., Lim, K.C. and Engel, J.D.
Development   133, 3871-3881  (2006)
 
Negative regulation of Nrf1 (nuclear factor-erythroid 2 p45-related factor 1) by its N-terminal domain is independent of Keap1: The Nrf1 and Nrf2 transcription factors are located to different sub-cellular compartments and are negatively controlled by distinct mechanisms.  
Zhang Y, Crouch DH, Yamamoto M, Hayes JD.
Biochem. J.   399, 373-385  (2006)
 
BRG1 Interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.  
Zhang, J., Ohta, T., Maruyama, A., Hosoya, T., Nishikawa, K., Maher, J.M., Shibahara, S., Itoh, K. and Yamamoto, M.
Mol. Cell. Biol.   26, 7942-7952  (2006)
 
Transgene insertion into the proximity of the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation.  
Mukai, H. Y., Motohashi, H., Ohneda, O., Suzuki, N., Nagano, M., Nagasawa, T. and Yamamoto, M.
Mol. Cell. Biol.   26, 7953-7965  (2006)
 
GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivo.  
Hosoya-Ohmura, S., Mochizuki, N., Suzuki, M., Ohneda, O., Ohneda, K. and Yamamoto, M.
J. Biol. Chem.   281, 32820-32830  (2006)
 
2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis.  
Matsumoto, K., Imagawa, S., Obara, N., Suzuki, N., Takahashi, S., Nagasawa, T. and Yamamoto, M.
J. Cell. Physiol.   209, 333-340  (2006)
 
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species.  
Kobayashi, M. and Yamamoto, M.
Adv. Enz. Regl. Elsevier Science B.V., New York   46, 113-140  (2006)
 
Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals.  
Uwayama J, Hirayama A, Yanagawa T, Warabi E, Sugimoto R, Itoh K, Yamamoto M, Yoshida H, Koyama A and Ishii T.
Biochem Biophys Res Commun   339, 226-231  (2006)
 
Wilms’ tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. 
Horiuchi K, Umetani M, Minami T, Okayama H, Takeda S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, and Kodama T.
Proc Natl Acad Sci USA   103, 17278-17283  (2006)
 
Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin and CD34 in the mouse embryo.  
Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M and Takahashi S.
Blood   108, 4018-4024  (2006)
 
Shear stress stabilizes NF-E2 related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species. 
Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, T Ishii T, Kodama T, and Noguchi N.
Free Rad Biol Med    42, 260-269  (2006)
 
Unique and overlapping transcriptional roles of Arnt (Arylhydrocarbon receptor nuclear translocator) and Arnt2 in xenobiotic and hypoxic responses.  
Sekine H, Mimura J, Yamamoto M and Fujii-Kuriyama Y.
J Biol Chem    281, 37507-37516  (2006)
 
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo [4,5-f] quinoline.  
Kitamura Y, Umemura T, Kanki K, Kodama Y, Kitamoto S, Saito K, Itoh K, Yamamoto M, Masegi T, Nishikawa A, and Hirose M.
Cancer Sci    [Epub ahead of print] ,   (2006)
 
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. 
Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, and Biswal S.
Biochem Biophys Res Commun    351, 883-889  (2006)
 
Real-time monitoring of stress erythropoiesis in vivo using Gata1- and β-globin LCR-luciferase transgenic mice.  
Suzuki M, Ohneda K, Ohmura S, Tsukamoto S, Ohneda O, Philipsen S, and Yamamoto M.
Blood   108(2), 726-33  (2006)

　日本語著書 (Publications in Japanese)
　
 
赤血球の生化学と機能/ ヘモグロビンの構造と機能 
向井陽美，山本雅之
「血液病学」   第３版,   (2006)
 
転写因子・転写制御キーワードブック  
田村隆明・山本雅之 編
羊土社   ,   (2006)
 
Keap1-Nrf2システムが担う生体防御機構 
勝岡史城，山本雅之
細胞工学   25, 153-156  (2006)
 
Keap1-Nrf2システムによるレドックスシグナル応答メカニズム 
鈴木隆史、山本雅之
実験医学   24, 1737-1743  (2006)

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