Publications 2013  
 Original Paper
 
 
Roles of keap1-nrf2 system in upper aerodigestive tract carcinogenesis. 
Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M.
Cancer Prev Res    6(2), 149-59  (2013)
大学院生大越明さんの論文です
 
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. 
Guiu J, Shimizu R, D'Altri T, Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.
J Exp Med.    210(1), 71-84  (2013)
 
Redox-sensitive transcription factor nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. 
Ashino T, Yamamoto M, Yoshida T, Numazawa S.
Arterioscler Thromb Vasc Biol.   33(4), 760-8  (2013)
 
The absence of macrophage Nrf2 promotes early atherogenesis. 
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL.
Cardiovasc Res.    98(1), 107-15  (2013)
 
Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. 
Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Yamamoto M, Zhang Q, Andersen ME, Pi J.
Diabetes   62(3), 845-54  (2013)
 
Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels. 
Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H, Yamamoto M.
Mol Cell Biol.   33(12), 2402-12  (2013)
鈴木隆史助教の論文です
 
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome. 
Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
Blood   121(16), 1687-95  (2013)
 
Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model. 
Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe O, Engel JD, Yamamoto M.
Mol Cell Biol.    33(8), 1687-95  (2013)
 
Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis. 
Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M.
Cancer Res    73(13), 4158-68  (2013)
研究員佐藤大希さんの論文です
 
NF-E2 p45 Is Important for Establishing Normal Function of Platelets. 
Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M, Motohashi H.
Mol Cell Biol.    33(14), 2659-70  (2013)
大学院生藤田理恵さんの論文です
 
The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus 
Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, and Yamamoto M.
Mol Cell Biol.    33(15), 2996-3010  (2013)
宇留野晃講師の論文です
 
Transforming Growth Factor-β Induces transcription factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene 
Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M.
J Biol Chem.   288(28), 20658-20667  (2013)
 
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. 
Holmström KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY.
Biol Open.   2(8), 761-70  (2013)
 
The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. 
Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T.
Am J Respir Cell Mol Biol.   49(2), 324-33  (2013)
 
Renal erythropoietin-producing cell-derived myofibroblasts govern fibrosis and posses profound plasticity. 
Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M.
J Am Soc Nephrol    24(10), 1599-1616  (2013)
研究員相馬友和さんの論文です
 
Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain. 
Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M.
Genes Cells.    18(10), 886-98  (2013)
 
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy. 
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.
Mol Cell.    51(5), 618-31  (2013)
 
Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice. 
Muramatsu H, Katsuoka F, Toide K, Shimizu Y, Furusako S, Yamamoto M.
Genes Cells.   18(10), 899-908  (2013)
研究員村松裕行さんの論文です
 
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome. 
Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
Blood.    121(16), 3181-4  (2013)
 
Keap1-Nrf2 Complex in Ischemia-Induced Hepatocellular Damage of Mouse Liver Transplants. 
Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW.
J Hepatol.   59(6), 1200-1207  (2013)
 
GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. 
Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M.
Genes Cells.   18(11), 921-933  (2013)
 
The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs. 
Takai J, Moriguchi T, Suzuki M, Lei Y, Ohneda K, Yamamoto M.
Blood.   122(20), 3450-3460  (2013)
大学院生高井淳さんの論文です
 
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. 
Holmström KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY.
Biol Open   2(8), 761-770  (2013)
 
A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, Yamamoto M.
Nature Commun   4, 1950  (2013)
大学院生山崎瞬さんの論文です
 
Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in nrf2. 
Cho HY, Gladwell W, Yamamoto M, Kleeberger SR.
Oxid Med Cell Longev.   2013, 254069  (2013)
 
4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation. 
Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H.
PLoS One.   8(7), e69415  (2013)
 
Indoxyl Sulfate Down-Regulates SLCO4C1 Transporter through Up-Regulation of GATA3. 
Akiyama Y, Kikuchi K, Saigusa D, Suzuki T, Takeuchi Y, Mishima E, Yamamoto Y, Ishida A, Sugawara D, Jinno D, Shima H, Toyohara T, Suzuki C, Souma T, Moriguchi T, Tomioka Y, Ito S, Abe T
PLoS One.   8(7), e66518  (2013 )
 
Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. 
Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M.
J Biol Chem.    288(28), 20658-20667  (2013)
 
Verification of the in vivo activity of three distinct cis-acting elements within the Gata1 gene promoter-proximal enhancer in mice. 
Shimizu R, Hasegawa A, Ottolenghi S, Ronchi A, Yamamoto M.
Genes Cells.    18(11), 1032-1041  (2013)

 日本語著書 (Publications in Japanese)
 
 
表皮の酸化ストレスとその防御機構 
小林枝里、日高高徳、山本雅之
FRAGRANCE JOURNAL   41(2), 16-21  (2013)

 Review
 
 
Toward clinical application of the Keap1-Nrf2 pathway. 
Suzuki T, Motohashi H, Yamamoto M.
Trends Pharmacol Sci.   34(6), 340-346  (2013)
鈴木隆史講師の総説です
 
Roles Nrf2 Plays in Myeloid Cells and Related Disorders, 
Eri Kobayashi, Takafumi Suzuki and Masayuki Yamamoto,
Oxid Med Cell Longev.    2013, 529219  (2013)

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