Publications 2014 
 Original Paper
 
 
Notch-nrf2 axis: regulation of nrf2 gene expression and cytoprotection by notch signaling. 
Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW.
Mol Cell Biol.   34(4), 653-663  (2014)
 
Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice. 
Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M.
Diabetes.    63(2), 605-618  (2014)
大学院生柳下陽子さんの論文です
 
Nrf2 enhances cholangiocyte expansion in pten-deficient livers. 
Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, Yamamoto M.
Mol Cell Biol.   34(5), 900-913  (2014)
田口恵子助教の論文です
 
Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1. 
Fukutomi T, Takagi K, Mizushima T, Ohuchi N, Yamamoto M.
Mol Cell Biol.   34(5), 832-846  (2014)
研究員福富俊明さんの論文です。雑誌の表紙に写真が掲載されました!
 
NRF2 immunolocalization in human breast cancer patients as a prognostic factor. 
Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, Suzuki T.
Endocr Relat Cancer.   21(2), 241-252  (2014)
 
Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by Keratin 14 promoter. 
Murakami S, Yamamoto M, and Motohashi H.
Toxicol Sci    138, 47-58  (2014)
大学院生村上昌平さんの論文です
 
Carbocisteine reduces viral-induced pulmonary inflammation in mice exposed to cigarette smoke.  
Yageta Y, Ishii Y, Morishima Y, Ano S, Ohtsuka S, Matsuyama M, Takeuchi K, Itoh K, Yamamoto M, and Hizawa N.
Am J Respir Cell Mol Biol   50(5), 963-973  (2014)
 
Possible involvementof nuclear factor erythroid 2-related factor 2in the gene expression of Cyp2b10and Cyp2a5. 
Ashino T, Ohkubo-Morita H, Yamamoto M, Yoshida T, and Numazawa S.
Redox Biology   2, 284-288  (2014)
 
Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice.  
Shirasaki K, Taguchi K, Unno M, Motohashi H, and Yamamoto M.
Hepatology   59(6), 2371-2382  (2014)
大学院生白崎圭一さんの論文です
 
Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.  
Murakami S, Shimizu R, Romeo P-H, Yamamoto M, and Motohashi H
Genes Cells    19, 239-253  (2014)
大学院生村上昌平さんの論文です
 
Keap1 inhibition attenuates glomerulosclerosis.  
Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, and Matsusaka T.
Nephrol Dial Transplant    29, 783-791  (2014)
 
Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. 
Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, and Yamamoto M.
Mol Cell Biol   34, 1812-1826  (2014)
 
GATA2 regulates body-water homeostasis through maintaining Aquaporin 2 expression in renal collecting ducts.  
Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, Engel JD, and Yamamoto M.
Mol Cell Biol    34, 1929-1941  (2014)
大学院生Yu Leiさんの論文です。
 
Continual extension and fragmentation of spermatogonial syncytia maintain the stem cell pool in mouse testis. 
Hara K, Nakagawa T, Enomoto H, Suzuki M, Yamamoto M, Simons BD, and Yoshida S.
Cell Stem Cel   14, 658–672  (2014)
 
The circadian clock regulates the NRF2/ARE-mediated antioxidant defence pathway in the mouse lung.  
Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GTJ, Fukada Y, and Meng Q-J.
Genes Dev   28, 548-560  (2014)
 
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.  
Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, and Yamamoto M.
Cancer Cell   25, 415-427  (2014)
大学院生山㟢博未さんの論文です。雑誌の表紙にイラストが採用されました!
 
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.  
Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, and Akaike T.
Proc Natl Acad Sci USA   111(21), 7606-7611  (2014)
 
Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity. 
Kärkkäinen V, Pomeshchik Y, Savchenko E, Dhungana H, Kurronen A, Lehtonen S, Naumenko N, Tavi P, Levonen AL, Yamamoto M, Malm T, Magga J, Kanninen KM, Koistinaho J.
Stem Cell   32(7), 1904-1916  (2014)
 
Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. 
Wang W, Li S, Wang H, Li B, Shao L, Lai Y, Horvath G, Wang Q, Yamamoto M, Janicki JS, Wang XL, Tang D, Cui T.
J Mol Cell Cardiol.   72, 305-315  (2014)
 
GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor. 
Takagi K, Moriguchi T, Miki Y, Nakamura Y, Watanabe M, Ishida T, Yamamoto M, Sasano H, Suzuki T.
Cancer Sci.    105(5), 600-6007  (2014)
 
Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis. 
Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, Yamamoto M.
Cancer Prev Res   7(8), 835-844  (2014)
大学院生平本圭一郎さん、研究員佐藤大希さん、鈴木隆史講師の論文です。雑誌の表紙に写真が掲載されました。
 
Loss of Nrf2 in Mice Evokes a Congenital Intrahepatic Shunt that Alters Hepatic Oxygen and Protein Expression Gradients and Toxicity. 
Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, Kensler TW.
Toxicol Sci.   141, 112-119  (2014)
 
Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway. 
Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M
J Biol Chem.   289(36), 24944-24955  (2014)
 
Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. 
Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, Yamamoto M.
Genes Cells.   19(8), 650-665  (2014)
弘津陽介さん、研究員東知佳さんの論文です
 
Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes. 
Tsujita T, Mullin V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, Hayes JD.
Mol Cell Biol.    34, 3800-3816  (2014)
辻田忠志助教の論文です
 
Nuclear Factor Erythroid 2-Related Factor 2 Regulates Toll-Like Receptor 4 Innate Responses in Mouse Liver Ischemia-Reperfusion Injury Through Akt-Forkhead box Protein O1 Signaling Network. 
Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW.
Transplantation.    98, 721-728  (2014)
 
Nrf2 induces fibroblast growth factor 21 in diabetic mice. 
Furusawa Y, Uruno A, Yagishita Y, Higashi C, Yamamoto M.
Genes Cells.   19(12), 864-878  (2014)
古澤祐樹さんの論文です
 
Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. 
Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, Sanyal AJ.
Cell Death Differ.   21(8), 1303-1312  (2014)
 
Remarkable induction of UV-signature mutations at the 3'-cytosine of dipyrimidine sites except at 5'-TCG-3' in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice. 
Ikehata H, Chang Y, Yokoi M, Yamamoto M, Hanaoka F
DNA Repair   22, 112-122  (2014)
池畑講師の論文です。
 
An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer. 
Katsuoka F, Yokozawa J, Tsuda K, Ito S, Pan X, Nagasaki M, Yasuda J Yamamoto M.
Anal Biochem.   466, 27-29  (2014)
 
Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM. 
Hirano K, Kinoshita T, Uemura T, Motohashi H, Watanabe Y, Ebihara T, Nishiyama H, Sato M, Suga M, Maruyama Y, Tsuji NM, Yamamoto M, Nishihara S, Sato C.
Ultramicroscopy.   143, 52-66  (2014)
 
PGC-1 coactivator activity is required for murine erythropoiesis. 
Cui S, Tanabe O, Lim KC, Xu HE, Zhou XE, Lin JD, Shi L, Schmidt L, Campbell A, Shimizu R, Yamamoto M, Engel JD.
Mol Cell Biol.   34(11), 1956-1965  (2014)
 
Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. 
Kato Kaneko M, Liu X, Oki H, Ogasawara S, Nakamura T, Saidoh N, Tsujimoto Y, Matsuyama Y, Uruno A, Sugawara M, Tsuchiya T, Yamakawa M, Yamamoto M, Takagi M, Kato Y.
Cancer Sci.    105(6), 744-748  (2014)
 
GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells. 
Kamata M, Okitsu Y, Fujiwara T, Kanehira M, Nakajima S, Takahashi T, Inoue A, Fukuhara N, Onishi Y, Ishizawa K, Shimizu R, Yamamoto M, Harigae H.
Haematologica.   99(11), 1686-1696  (2014)
 
Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. 
Kanamori M, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H, Tominaga T.
Neuro Oncol.   nou282  (2014)

 Review
 
 
A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation. 
Moriguchi T, and Yamamoto M.
Int J Hematol   100(5), 417-424  (2014)
 
Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies. 
Suzuki M, Yamamoto M, Engel JD.
Mol Cell Biol.   34(19), 3560-3569  (2014)

 日本語著書 (Publications in Japanese)
 
 
Gata1とGata2遺伝子ダイナミクスのネットワーク制御を基盤とした赤血球分化の分子機構 
森口 尚, 山本 雅之
臨床血液   55, 633-642  (2014)
 
酸化ストレス認識分子基盤と創薬応用 
辻田 忠志, 山本 雅之
『生命科学から創薬へのイノベーション』   第10章, 63-70  (2014)
 
エリスロポエチン産生細胞とエリスロポエチン遺伝子の発現制御機構 
山本 雅之, 平野 育生
臨床血液   55, 1785-1794  (2014)
 
Keap1-Nrf2システムによる酸化ストレス・親電子性物質応答機構   
田口恵子、山本雅之
酸化ストレスの医学 改訂第2版   53-59  (2014)
 
Nrf2による酸化ストレス糖尿病モデルマウスの膵β細胞保護機構 
柳下陽子、山本雅之
Diabetes Journal   3, 39-40  (2014)
 
Keap1-Nrf2系と腎臓病 
祢津昌広、相馬友和、山本雅之
Annual Review 腎臓2014   89-96  (2014)
 
腎エリスロポエチン産生細胞と腎臓病 
祢津昌広, 相馬友和, 山本雅之
日本臨牀    72(9), 1691-1700  (2014)
 
ゲノム医療の新展開 第1回 大規模なゲノム解析から未来型医療への新たな試み 
勝岡史城、山本雅之
Frontiers in Gastroenterology   19 , 36-39  (2014)
 
Keap1-Nrf2システムと毒物の解毒・排泄 
田口恵子
毒性の科学―分子・細胞から人間集団まで   28-33  (2014)
 
低酸素応答性転写因子HIFと疾患 
関根弘樹, Lorenz Poellinger, 鈴木教郎
細胞工学   33, 711-715  (2014)
 
EPO産生細胞 
鈴木教郎
全人力・科学力・透析力・for the people 透析医学   364–368  (2014)
 
赤血球分化の決定機構 
清水律子
血液フロンティア   24, 49-54  (2014)
 
マウス皮膚における紫外線突然変異作用スペクトルの解析 
池畑広伸
放射線生物研究   49(1), 1-13  (2014)
 
GATA転写因子群の生理機能と時空間特異的遺伝子発現制御機構 
森口尚
東北医学会雑誌   126, 36-42  (2014)

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