Publications 2021 
 Original Paper
 
 
NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer 
Baird L, Yamamoto M.
Mol Cell Biol.   41, e00473-20  (2021)
Liam Baird助教の論文です
 
Identification of dominant transcripts in oxidative stress response by a full-length transcriptome analysis 
Otsuki A, Okamura Y, Aoki Y, Ishida N, Kumada K, Minegishi N, Katsuoka F, Kinoshita K, Yamamoto M.
Mol Cell Biol.   41, e00472-20  (2021)
大槻晃史助教の論文です
 
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium 
Horiuchi M, Taguchi K, Hirose W, Tsuchida K, Suzuki M, Taniyama Y, Kamei T, Yamamoto M.
Mol Cell Biol.   41, e00536-20  (2021)
研究員の堀内真さんの論文です
 
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production 
Cvetko F, Caldwell ST, Higgins M, Suzuki T, Yamamoto M, Prag HA, Hartley RC, Dinkova-Kostova A, Murphy MP.
J Biol Chem.   296, 100169  (2021)
 
Defining the functionally sufficient regulatory region and liver-specific roles of the erythropoietin gene by transgene complementation 
Yamazaki S, Hirano I, Kato K, Yamamoto M, Suzuki N.
Life Sci.   269, 119075  (2021)
 
Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions 
Miyauchi K, Nakai T, Saito S, Yamamoto T, Sato K, Kato K, Nezu M, Miyazaki M, Ito S, Yamamoto M, Suzuki N.
EBioMedicine.   64, 103209  (2021)
 
Novel method for evaluating the health condition of mice in space through a video downlink 
Yumoto A, Kokubo T, Izumi R, Shimomura M, Funatsu O, Tada MN, Ota-Murakami N, Iino K, Shirakawa M, Mizuno H, Kudo T, Takahashi S, Suzuki T, Uruno A, Yamamoto M, Shiba D.
Exp Anim.   70, 236-244  (2021)
 
Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism 
Horie Y, Suzuki T, Inoue J, Iso T, Wells G, Moore TW, Mizushima T, Dinkova-Kostova AT, Kasai T, Kamei T, Koshiba S, Yamamoto M.
Commun Biol.   4, 576  (2021)
大学院生の堀江悠太さんの論文です
 
Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight 
Hayashi T, Kudo T, Fujita R, Fujita SI, Tsubouchi H, Fuseya S, Suzuki R, Hamada M, Okada R, Muratani M, Shiba D, Suzuki T, Warabi E, Yamamoto M, Takahashi S.
Commun Biol.   4, 787  (2021)
 
An erythroid to myeloid cell fate conversion is elicited by LSD1 inactivation 
Yu L, Myers G, Ku CJ, Schneider E, Wang Y, Singh SA, Jearawiriyapaisarn N, White A, Moriguchi T, Khoriaty R, Yamamoto M, Rosenfeld M, Pedron J, Bushweller JH, Lim KC, Engel JD.
Blood   138, 1691-1704  (2021)
 
Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice 
Yamaguchi A, Hirano I, Narusawa S, Shimizu K, Ariyama H, Yamawaki K, Nagao K, Yamamoto M, Shimizu R.
Genes Cells   26, 782-797  (2021)
 
Nrf2 Depletion Sensitizes Pancreatic Cancer Cells to Gemcitabine via Aldehyde Dehydrogenase 3a1 Repression 
Matsumoto R, Hamada S, Tanaka Y, Taguchi K, Yamamoto M, Masamune A.
J Pharmacol Exp Ther   379, 33-40  (2021)
 
Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction 
Zhang A, Suzuki T, Adachi S, Naganuma E, Suzuki N, Hosoya T, Itoh K, Sporn MB, Yamamoto M.
Mol Cell Biol.   41, e0023621  (2021)
大学院生の張安hさんの論文です
 
Nrf2 expression in pancreatic stellate cells promotes progression of cancer 
Tanaka Y, Hamada S, Matsumoto R, Taguchi K, Yamamoto M, Masamune A.
Am J Physiol Gastrointest Liver Physiol.   321, G378-G388  (2021)
 
NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition 
Waku T, Hagiwara T, Tamura N, Atsumi Y, Urano Y, Suzuki M, Iwami T, Sato K, Yamamoto M, Noguchi N, Kobayashi A.
iScience   24, 103180  (2021)
 
Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease 
Ahuja M, Ammal Kaidery N, Attucks OC, McDade E, Hushpulian DM, Gaisin A, Gaisina I, Ahn YH, Nikulin S, Poloznikov A, Gazaryan I, Yamamoto M, Matsumoto M, Igarashi K, Sharma SM, Thomas B.
Proc Natl Acad Sci U S A   118, e2111643118  (2021)
 
Nrf2 plays a critical role in the metabolic response during and after spaceflight 
Uruno A, Saigusa D, Suzuki T, Yumoto A, Nakamura T, Matsukawa N, Yamazaki T, Saito R, Taguchi K, Suzuki M, Suzuki N, Otsuki A, Katsuoka F, Hishinuma E, Okada R, Koshiba S, Tomioka Y, Shimizu R, Shirakawa M, Kensler TW, Shiba D, Yamamoto M.
Commun Biol   4, 1381  (2021)
宇留野晃准教授の論文です
 
Osteoclasts adapt to physioxia perturbation through DNA demethylation 
Nishikawa K, Seno S, Yoshihara T, Narazaki A, Sugiura Y, Shimizu R, Kikuta J, Sakaguchi R, Suzuki N, Takeda N, Semba H, Yamamoto M, Okuzaki D, Motooka D, Kobayashi Y, Suematsu M, Koseki H, Matsuda H, Yamamoto M, Tobita S, Mori Y, Ishii M.
EMBO Rep   22, e53035  (2021)

 Review
 

 日本語著書 (Publications in Japanese)
 
 
GATA2とEVI1の発現異常による骨髄系細胞の分化障害と白血病発症 
鈴木未来子、山本雅之
血液内科   82, 16-22  (2021)
 
新たなステージに入った宇宙ライフサイエンス研究 
芝 大、湯本 茜、岡田理沙、小林拓恵 、上村大輔 、白川正輝 、山本雅之
実験動物ニュース   70, 2-7  (2021)
 
環境応答・適応の分子機構 
田口恵子、山本雅之
日本体質医学会雑誌   83, 73-80  (2021)
田口恵子准教授の総説です

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